BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF

Provided herein are compounds of formula (I):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein.Also provided herein is a pharmaceutically acceptable composition comprising a compound...

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Bibliographische Detailangaben
Hauptverfasser:	KUROSAKI, Toshio, MAKINO, Takuya, KOIZUMI, Yuka, YAMAKI, Susumu, KURIWAKI, Ikumi, HONJO, Eriko, EVANS, Chris, LU, Pu-Ping, TSUCHIYA, Kazuyuki, WANG, Wenyue, SEKIOKA, Ryuichi, COLLIBEE, Scott, MORGAN, Bradley P, YAMASAKI, Makoto, KATOH, Naoto
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compounds of formula (I):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein.Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing.Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.