TRANSFORMED IMMUNE CELLS INDUCING CHEMOTAXIS TOWARDS HETEROGENEOUS IMMUNE CELLS

The present invention relates to immune cells expressing IL-7, CCL19 or a combination thereof, and a composition for the preventing or treating cancer or infectious diseases comprising the same as an active ingredient. The present invention may achieve a multifaceted and synergistic therapeutic effe...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, Milim, SON, Dohyun, CHOI, Ki Doo, OH, Sanghyeon
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to immune cells expressing IL-7, CCL19 or a combination thereof, and a composition for the preventing or treating cancer or infectious diseases comprising the same as an active ingredient. The present invention may achieve a multifaceted and synergistic therapeutic effect through administering a therapeutically effective amount of single type of immune cells, specifically natural killer cells, due to the complementary immune responses between the patient's endogenous T cells and injected natural killer cells. Co-administration of T cells and the immune cells other than T cells, specifically natural killer cells, also significantly improve therapeutic effects by allowing these heterogeneous cell populations to act in a lesion-concentrated manner.