ORAL LIQUID PHARMACEUTICAL COMPOSITIONS OF ISOTRETINOIN

ORAL LIQUID PHARMACEUTICAL COMPOSITIONS OF ISOTRETINOIN

The present invention relates to new stable oral liquid pharmaceutical compositions comprising isotretinoin (13-cis retinoic acid), pharmaceutically accepted salts thereof, or other suitable isotretinoin compounds. The compositions are formulated in a lipid carrier, typically comprising phospholipid...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MANDAPATI, Ravindhar, Reddy, SHAIK, Mahaboob, Basha, R. JOSHI, Mahendra, BANAVALI, Shripad, D, GOTA, Vikram, Prakash, KAKKAR, Archana, Khosa, CHINNASWAMY, Girish
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to new stable oral liquid pharmaceutical compositions comprising isotretinoin (13-cis retinoic acid), pharmaceutically accepted salts thereof, or other suitable isotretinoin compounds. The compositions are formulated in a lipid carrier, typically comprising phospholipids, and in embodiments comprising a substantial amount of one or more phosphatidylcholines. Such compositions can further comprise a surfactant component, a medium chain triglyceride component, an antioxidant/preservative component, or combination thereof. The present invention also provides the process of preparation of such compositions and methods of using such compositions in the treatment of various diseases/conditions.