ARTIFICIAL TUMOR TISSUE, METHODS, COMPOSITION AND USES THEREOF

The present disclosure relates to the in vitro generation of a stratified artificial tumor tissue spheroid model comprising pancreatic ductal adenocarcinoma cells and tumor microenvironment stromal components, for anti-cancer therapeutics screening, methods and uses thereof. The present disclosure a...

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Bibliographische Detailangaben
Hauptverfasser:	VINHAS MONTEIRO, Maria, ABREU GASPAR, Vítor Manuel, COLARDELLE DA LUZ MANO, João Filipe
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to the in vitro generation of a stratified artificial tumor tissue spheroid model comprising pancreatic ductal adenocarcinoma cells and tumor microenvironment stromal components, for anti-cancer therapeutics screening, methods and uses thereof. The present disclosure also relates to a hydrogel-embedded stratified microtumor tissue spheroid platform; to a kit for anti-cancer therapeutic screening for use in the therapy, diagnostic, or treatment of pancreatic cancer; and to an in vitro or ex vivo method for screening therapeutics/therapeutics combinations for use in the therapy, diagnostic, or treatment of pancreatic cancer. The present disclosure also relates to the fabrication of hydrogel-stratified pancreatic ductal adenocarcinoma cells and tumor microenvironment stromal components to generate stratified hydrogel-embedded tumor models that recapitulate tumor-stroma specific ECM spatial stratification.