GROWTH HORMONE FUSION PROTEIN AND PREPARATION METHOD AND USE THEREOF

The present disclosure relates to a growth hormone fusion protein and a preparation method and use thereof. The growth hormone fusion protein includes: a double-stranded structure having a first constant region Fc segment and a second constant region Fc segment; and a growth hormone linked to the fi...

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Bibliographische Detailangaben
Hauptverfasser:	WU, Qi, GUO, Liming, GAO, Xin, SUN, Baocai, WANG, Chao, LI, Jianan, BAO, Guoqing, SHEN, Yubao
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to a growth hormone fusion protein and a preparation method and use thereof. The growth hormone fusion protein includes: a double-stranded structure having a first constant region Fc segment and a second constant region Fc segment; and a growth hormone linked to the first constant region Fc segment, the growth hormone has no methionine at an N-terminus thereof, and the growth hormone fusion protein was expressed by a non-mammalian cell expression system. According to the present disclosure, by adopting the fusion of the growth hormone and the double-stranded structure, the in vivo half-life of the growth hormone can be prolonged, and since each double-stranded structure only carries one growth hormone, the active site of the growth hormone is not affected by steric hindrance, and stronger activity is provided, and since the N-terminus of the growth hormone has no methionine, higher safety is provided.