PREPARATION METHOD FOR CANNFLAVIN COMPOUNDS

Disclosed is a preparation method for cannflavin compounds. The preparation method has the advantages of cheap and easily available raw materials, few reaction steps, short production period, simple operation, etc. The method comprises: firstly, condensing 4'-hydroxy-3'-methoxyacetophenone...

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Bibliographische Detailangaben
Hauptverfasser: WANG, Shubin, LAN, Lan, MOU, Hongtao, DU, Yesong, LUO, Junlu, ZHANG, Pingping, TAN, Xin
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Disclosed is a preparation method for cannflavin compounds. The preparation method has the advantages of cheap and easily available raw materials, few reaction steps, short production period, simple operation, etc. The method comprises: firstly, condensing 4'-hydroxy-3'-methoxyacetophenone and diethyl carbonate (DEC) under an alkaline condition to obtain 4'-hydroxy-3'-methoxybenzoyl acetate; reacting 1,3,5-trihydroxybenzene with bromo-isoamylene under an alkaline condition to obtain 2-isopentenyl-1,3,5-trihydroxybenzene; and finally, condensing 4'-hydroxy-3'-methoxybenzoyl acetate and 2-isopentenyl-1,3,5-trihydroxybenzene at a high temperature to produce cannflavin B and/or isocannflavin B, and then subjecting same to separation and purification to obtain pure cannflavin B and pure isocannflavin B.