FORMULATIONS OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES

FORMULATIONS OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES

The invention relates to the preparation, optimization, and characterization of the formulations of liquid self-nanoemulsifying drug delivery systems (SNEDDS) containing bosentan monohydrate (BOS) using long-chain mono and diglyceride mixtures. BOS-containing liquid SNEDDS, Glyceryl monolinoleate (M...

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Bibliographische Detailangaben
Hauptverfasser: YILMAZ USTA, Duygu, TEKSIN, Zeynep Safak
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to the preparation, optimization, and characterization of the formulations of liquid self-nanoemulsifying drug delivery systems (SNEDDS) containing bosentan monohydrate (BOS) using long-chain mono and diglyceride mixtures. BOS-containing liquid SNEDDS, Glyceryl monolinoleate (Maisine®) - Polyoxyl 40 hydrogenated castor oil (Cremophor® RH 40) - Caprilocaproil polyoxyl-8 glycerides (Labrasol®) and Glyceryl monooleate (Peceol®) - Polyoxyl 40 hydrogenated castor oil (Cremophor® RH 40) - Caprylocaproyl polyoxyl-8 glycerides (Labrasol®) from certain proportions of formed, and the systems were determined by water titration method.