1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-B]PYRAZIN-2(1H)-ONE FOR TREATING GLIOBLASTOMA MULTIFORME

1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-B]PYRAZIN-2(1H)-ONE FOR TREATING GLIOBLASTOMA MULTIFORME

Provided herein is a compound for use in a method for treating locally advanced, recurrent or metastatic glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) protein expression and/or MGMT promoter hypomethylation in a patient, wherein the method comprises adm...

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Bibliographische Detailangaben
Hauptverfasser: HEGE, Kristen Mae, RAYMON, Heather
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein is a compound for use in a method for treating locally advanced, recurrent or metastatic glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) protein expression and/or MGMT promoter hypomethylation in a patient, wherein the method comprises administering an effective amount of said compound to said patient; wherein said compound is 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof.