IMPROVED METHODS AND COMPOSITIONS FOR EXPRESSION OF NUCLEIC ACIDS IN CELLS

IMPROVED METHODS AND COMPOSITIONS FOR EXPRESSION OF NUCLEIC ACIDS IN CELLS

Compositions and methods for making and using engineered phagocytic cells that express a chimeric antigen receptor having an enhanced phagocytic activity for stable and durable expression are described and can be suitably used for immunotherapy in cancer or infection.

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Bibliographische Detailangaben
Hauptverfasser: SHCHERBAKOVA, Inna, GETTS, Daniel, ROWLEY JR., William F, WANG, Yuxiao, BISARIA, Namita
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compositions and methods for making and using engineered phagocytic cells that express a chimeric antigen receptor having an enhanced phagocytic activity for stable and durable expression are described and can be suitably used for immunotherapy in cancer or infection.