CIRCULATING MIRNAS AS PREDICTIVE BIOMARKERS OF THE RISK OF CARDIAC ISCHEMIA IN PATIENTS WITH CHEST PAIN

The present invention refers to an in vitro method for predicting the risk of myocardial ischemia in patients with chest pain based on the determination of the expression levels of at least one of the miRNAs from a panel of miRNA biomarkers comprising: hsa-miR-10b-5p, hsa-miR-1199-5p, hsa-miR-1249-3p, hsa-miR-1253, hsa-miR-125b-2-3p, hsa-miR-1290, hsa-miR-1306-5p, hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-216a-5p, hsa-miR-218-5p, hsa-miR-3164, hsa-miR-328-5p, hsa-miR-329-3p, hsa-miR-365a-5p, hsa-miR-3675-3p, hsa-miR-410-3p, hsa-miR-4488, hsa-miR-4786-5p, hsa-miR-493-5p, hsa-miR-5006-5p, hsa-miR-615-3p, hsa-miR-657, hsa-miR-671-5p, hsa-miR-6865-3p, hsa-miR-7106-3p, hsa-miR-9-5p, hsa-miR-1260a, hsa-miR-214-3p, hsa-miR-6889-5p, hsa-miR-8485, hsa-miR-877-3p, hsa-miR-1-3p, hsa-let-7c-5p, hsa-miR-4732-3p, hsa-let-7a-5p, hsa-miR-221-3p, hsa-miR-342-3p, hsa-miR-494-3p, hsa-miR-92b-3p or any combination thereof, in a biological sample isolated from the patient. The present invention also refers to said panel of 40 circulating miRNAs and its use as biomarker of the risk of myocardial ischemia in patients with chest pain.