[ 18F]-LABELED IMIDAZOPYRIDINE DERIVATIVES AS PET RADIOTRACER

The present disclosure relates to [18F]-labeled imidazopyridine derivatives or salts thereof as positron emission tomography (PET) radiotracers suitable for imaging the stress-signaling non-receptor tyrosine kinase c-abl, and their use in in vivo diagnosis, preclinical and clinical imaging, patient...

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Bibliographische Detailangaben
Hauptverfasser: NAM, Hwajung, LEE, Jinhwa
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present disclosure relates to [18F]-labeled imidazopyridine derivatives or salts thereof as positron emission tomography (PET) radiotracers suitable for imaging the stress-signaling non-receptor tyrosine kinase c-abl, and their use in in vivo diagnosis, preclinical and clinical imaging, patient stratification on the basis of mutational status of c-abl and assessing response to therapeutic treatments. The present disclosure furtherrelates to the use of [18F]-labeled imidazopyridine derivatives as PET radiotracers. Thedis-closure also provides a process for the radiosynthesis of [18F]-labeled imidazopyridinederivatives.