HYDROGEL FORMULATION COMPRISING ZEBULARINE AND RETIONIC ACID

A pharmaceutical composition comprising two hydrogel formulations with biologically active substances for simultaneous use, one mixture of which comprises not less than 60 and not more than 240 mg of zebularine added to 1 ml of sodium alginate hydrogel, and the other mixture of which comprises not l...

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Hauptverfasser: Sass, Piotr, Baczynski-Keller, Jakub, Sachadyn, Pawel, Slonimska, Paulina, Dzierzynska, Maria, Pikula, Michal, Deptula, Milena, Skowron, Piotr, Sawicka, Justyna, Kaminska, Jolanta, Rodziewicz-Motowidlo, Sylwia, Platek, Rafal, Sosnowski, Pawel
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A pharmaceutical composition comprising two hydrogel formulations with biologically active substances for simultaneous use, one mixture of which comprises not less than 60 and not more than 240 mg of zebularine added to 1 ml of sodium alginate hydrogel, and the other mixture of which comprises not less than 1 and not more than 4 mg of retinoic acid added to 1 ml of sodium alginate hydrogel, wherein the biologically active substances, i.e. zebularine and retinoic acid, release gradually from each formulation due to hydrogel biodegradation, which allows their combined action to be used to stimulate complex tissue regeneration.