LUMEN INSERTABLE CAPSULE

A capsule (100) suitable for insertion into a gastrointestinal lumen. The capsule (100) comprises: a capsule housing (110, 120), a reservoir (A) accommodating a drug substance, a drug outlet (190), an actuation chamber (118), a movable separator (160) between the actuation chamber (118) and the rese...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JEPSEN, Jacob, Pyung, Hwa, JAKOBSEN, Nikolaj, Eusebius, MOURIDSEN, Brian, STICKER, Drago, GHAZAL, Aghiad
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:A capsule (100) suitable for insertion into a gastrointestinal lumen. The capsule (100) comprises: a capsule housing (110, 120), a reservoir (A) accommodating a drug substance, a drug outlet (190), an actuation chamber (118), a movable separator (160) between the actuation chamber (118) and the reservoir (A), and a drive system comprising a gas expansion unit (150) and a trigger (145, 140, 170). The gas expansion unit (150) comprises a gas gate (151) and the trigger (145, 140, 170) comprises a trigger member (170) and a swellable portion (140) comprising sponge material, wherein wetting of the sponge material causes swelling of the sponge material thereby causing relative movement between the gas expansion unit (150) and the trigger member (170) to open the gas gate (151). Pressurized gas flows from them to the actuation chamber (118) thereby exerting load on the separator (160) for expelling the drug substance.