THERAPEUTIC AND DIAGNOSTIC VHH ANTIBODIES AGAINST SARS-COV-2 AND METHODS FOR THEIR ENHANCEMENT

The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2, a strategy...

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Hauptverfasser:	GUNKEL, Philip, METIN, Aksu, TAXER, Waltraud, NEUMANN, Leonie, DOBBELSTEIN, Matthias, GÖRLICH, Dirk, MUSSIL, Bianka, KRULL, Jens, RYMARENKO, Oleh, DICKMANNS, Antje, CORDES, Volker, GREGOR, Kathrin, GÜTTLER, Thomas, TEICHMANN, Ulrike, SCHÜNEMANN, Jürgen, PLEINER, Tino, STEGMANN, Kim Maren, REES, Renate
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2, a strategy for an enhanced block of the homotrimeric viral spike proteins by symmetry-matching VHH-fusions, implementations of this strategy, as well as VHH antibodies for sensitive detection of SARS-CoV2-infections.