SHAPE-GUIDED CONTROLLED RELEASE AND RETENTION WITH STRUCTURES INCLUDING CROSSLINKED POLY(GLYCEROL SEBACATE)

SHAPE-GUIDED CONTROLLED RELEASE AND RETENTION WITH STRUCTURES INCLUDING CROSSLINKED POLY(GLYCEROL SEBACATE)

A delivery system is described that includes a controlled release device that includes a crosslinked poly(glycerol sebacate) (PGS) or other glycerol ester and a controlled release compound, the controlled release device being provided in a contracted state and being expandable to a three-dimensional...

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Bibliographische Detailangaben
Hauptverfasser: GABRIELE, Peter D, STAHL, Alexander M, BAKER, Manasi Chawathe, REED, Stephanie, WEBER, Amanda K
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A delivery system is described that includes a controlled release device that includes a crosslinked poly(glycerol sebacate) (PGS) or other glycerol ester and a controlled release compound, the controlled release device being provided in a contracted state and being expandable to a three-dimensional expanded state in a target location. The delivery systems provides an expandible, flexible biodegradable elastomer loaded with an active ingredient to allow for extended release for different dosage forms for either human or animal health products in vivo, delivered through the gastrointestinal tract.