ANTISENSE OLIGONUCLEOTIDES FOR RNA EDITING

The invention relates to a composition comprising a set of two single stranded antisense oligonucleotides (AONs), wherein one AON is the 'Editing AON' and the other AON is the 'Helper AON', for use in the deamination of a target adenosine in a target RNA to an inosine, wherein th...

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Hauptverfasser:	VAN SINT FIET, Lenka, SOLER CANTÓN, Alicia
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a composition comprising a set of two single stranded antisense oligonucleotides (AONs), wherein one AON is the 'Editing AON' and the other AON is the 'Helper AON', for use in the deamination of a target adenosine in a target RNA to an inosine, wherein the Editing AON is complementary to a stretch of nucleotides in the target RNA that includes the target adenosine, wherein the Helper AON is complementary to a stretch of nucleotides in the target RNA that is separate from the stretch of nucleotides that is complementary to the Editing AON, wherein the Helper AON has a length of 16 to 22 nucleotides and the Editing AON has a length of 16 to 22 nucleotides.