COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

The present invention relates to the field of compositions and methods for the treatment of cancer. In particular, the invention relates to novel melittin fusion peptides including an RGD-motif containing peptide that binds to the integrins αvβ6 and αvβ3. Preferably the RGD-motif containing fusion p...

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Hauptverfasser:	DUFFY, Ciara, BLANCAFORT, Pilar
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the field of compositions and methods for the treatment of cancer. In particular, the invention relates to novel melittin fusion peptides including an RGD-motif containing peptide that binds to the integrins αvβ6 and αvβ3. Preferably the RGD-motif containing fusion peptide can reduce viability of cancer cells, including in particular, TNBC and HER2-enriched breast cancer cells, and ovarian cancer cells.