PLASMA KALLIKREIN INHIBITORS

PLASMA KALLIKREIN INHIBITORS

The present invention provides a compound of Formula Iand pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TIAN, Maoqun, HICKS, Jacqueline, D, ZHAO, Zhiqiang, SINZ, Christopher, J, SHARP, Phillip Patrick, SHEARN-NANCE, Galen Paul, LOMBARDO, Matthew, J, BAO, Jianming, KUANG, Rongze, LOPEZ, Jovan Alexander, CHENG, Alan, C, YANG, Song, WU, Zhicai, MERCHANT, Rohan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a compound of Formula Iand pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.