FGFR1/KLB TARGETING AGONISTIC ANTIGEN-BINDING PROTEINS AND CONJUGATES THEREOF WITH GLP-1R AGONISTIC PEPTIDES

FGFR1/KLB TARGETING AGONISTIC ANTIGEN-BINDING PROTEINS AND CONJUGATES THEREOF WITH GLP-1R AGONISTIC PEPTIDES

Provided herein are FGFR1/KLB targeting agonistic antigen-binding proteins, or fragments thereof, having improved physico-chemical properties. Also provided herein are conjugates comprising an FGFR1/KLB targeting agonistic antigen-binding protein, or a fragment thereof, and at least one GLP-1R agoni...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DREYER, Matthias, LANGE, Christian, SCHWAHN, Uwe, HÖLPER, Soraya, SOMMERFELD, Mark, RUDOLPH, Christine, DITTRICH, Werner, LANGER, Thomas, LORENZ, Katrin
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are FGFR1/KLB targeting agonistic antigen-binding proteins, or fragments thereof, having improved physico-chemical properties. Also provided herein are conjugates comprising an FGFR1/KLB targeting agonistic antigen-binding protein, or a fragment thereof, and at least one GLP-1R agonistic peptide. Further provided are pharmaceutical compositions comprising the antibody (or fragment thereof), or the conjugate provided herein, and the use of the antibody (or fragment thereof), or the use of the conjugate in medicine.