SOLID STATE FORMS OF AVAPRITINIB SALTS

SOLID STATE FORMS OF AVAPRITINIB SALTS

The present disclosure encompasses solid state forms of Avapritinib salts and co-crystals of the hydrochloride salt of Avapritinib, processes for preparation thereof, and pharmaceutical compositions thereof as well as their pharmaceutical use, in particular in the treatment of gastrointestinal strom...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SOMASUNDARAM, Meenakshi Sundaram, MUPPALLA, Siva Rama Krishna, WAGH, Yogesh Dhananjay, LUTHRA, Parven Kumar, MUTHUSAMY, Anantha Rajmohan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure encompasses solid state forms of Avapritinib salts and co-crystals of the hydrochloride salt of Avapritinib, processes for preparation thereof, and pharmaceutical compositions thereof as well as their pharmaceutical use, in particular in the treatment of gastrointestinal stromal tumors (GIST), solid tumors and Advanced Systemic Mastocytosis.