PD-L1 ANTIBODIES, FUSION PROTEINS, AND USES THEREOF

Disclosed herein are anti-PD-L1 antibodies and antigen-binding fragments thereof, fusion proteins comprising a first domain comprising an anti-PD-L1 antibodies or an antigen-binding fragment thereof and a second domain comprising a fragment of TGFβRII that binds TGFβ or a variant thereof, as well as...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG, Yu, ZHOU, Zhou, DONG, Xin, ZHAO, Lianqi, WANG, Binbin, DONG, Jinyu, WANG, Dong, WANG, Baiyang, SHAO, Liegang
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed herein are anti-PD-L1 antibodies and antigen-binding fragments thereof, fusion proteins comprising a first domain comprising an anti-PD-L1 antibodies or an antigen-binding fragment thereof and a second domain comprising a fragment of TGFβRII that binds TGFβ or a variant thereof, as well as polynucleotides that encode such antibodies or fusion proteins. Disclosed herein are also their uses in treatment of diseases such as cancers.