IMPROVED PROCESS FOR PREPARATION OF SITAGLIPTIN

A process for the preparation of specific enantiomeric Sitagliptin with good chiral purity and higher yield using improved biocatalyst and by engineering an enzyme to mediate the efficient conversion of ketoamide to obtain enatiomerically pure Sitagliptin in presence of an amino group donor.

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Bibliographische Detailangaben
Hauptverfasser:	DESAI, Parimal Hasmukhlal, SALPURE, Navnath Gorakshanath, YADAV, Rajendra Babasaheb, PATRAVALE, Bharatkumar Surendra, SALUNKE, Chetan Liladhar, KAJALE, Nitin Baburao, SALVI, Narendra Jagannath
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	A process for the preparation of specific enantiomeric Sitagliptin with good chiral purity and higher yield using improved biocatalyst and by engineering an enzyme to mediate the efficient conversion of ketoamide to obtain enatiomerically pure Sitagliptin in presence of an amino group donor.