ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER

The present invention encompasses compounds of formula (I)wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compo...

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Bibliographische Detailangaben
Hauptverfasser:	MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, WATERSON, Alex, FESIK, Stephen W, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas, KAROLYI-OEZGUER, Jale
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention encompasses compounds of formula (I)wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.