METHODS AND COMPOSITIONS FOR TREATING STROKE

METHODS AND COMPOSITIONS FOR TREATING STROKE

Compositions and methods for treating stroke in a mammalian subject are provided. The compositions and methods generally entail administration of an effective amount of a growth and differentiation factor 11 (GDF 11) molecule to a subj ect initiating within a short time window after a stroke event,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SINHA, Manisha, ALLEN, Mark Felder, SANDRASAGRA, Anthony, WANG, Yongting
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compositions and methods for treating stroke in a mammalian subject are provided. The compositions and methods generally entail administration of an effective amount of a growth and differentiation factor 11 (GDF 11) molecule to a subj ect initiating within a short time window after a stroke event, wherein the GDF 11 molecule is administered at a high dose relative to the body weight of the subject and such administration regimen is carried out over a short period of time ranging from 1 to about 14 days.