PREDICTING DISEASE OUTCOMES USING MACHINE LEARNED MODELS

Embodiments of the disclosure include implementing a ML-enabled cellular disease model for validating an intervention, identifying patient populations that are likely responders to an intervention, and developing a therapeutic structure-activity relationship screen. To generate a cellular disease mo...

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Hauptverfasser: SALICK, Max, R, KOLLER, Daphne, KAYKAS, Ajamete, STANITSAS, Panagiotis Dimitrios, SHARON, Eilon, RIESSELMAN, Adam, Joseph, KATEGAYA, Lorn, COTTA-RAMUSINO, Cecilia, Giovanna, Silvia, CASALE, Francesco Paolo, SULTAN, Mohammad Muneeb, PALMEDO, Peter, Franklin, Jr
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Embodiments of the disclosure include implementing a ML-enabled cellular disease model for validating an intervention, identifying patient populations that are likely responders to an intervention, and developing a therapeutic structure-activity relationship screen. To generate a cellular disease model, data is combined from human genetic cohorts, from the literature, and from general-purpose cellular or tissue-level genomic data to unravel the set of factors (e.g., genetic, environmental, cellular factors) that give rise to a particular disease. In vitro cells are engineered using the set of factors to generate training data for training machine learning models that are useful for implementing cellular disease models.