OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF

The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified olig...

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Bibliographische Detailangaben
Hauptverfasser: LIU, Yuanjing, MARAPPAN, Subramanian, KHAN, Akbar Husain, ANDREUCCI, Amy Jada, KUMARASAMY, Jayakanthan, BOMMINENI, Gopal Reddy, IWAMOTO, Naoki, SHIMIZU, Mamoru, STANDLEY, Stephany Michelle, CHIVATAKARN, Onanong, VARGEESE, Chandra, LU, Genliang, KANDASAMY, Pachamuthu
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.