COMPOSITIONS AND METHODS FOR THE DELIVERY OF AGENTS TO BIOLOGICAL TARGETS

COMPOSITIONS AND METHODS FOR THE DELIVERY OF AGENTS TO BIOLOGICAL TARGETS

The present invention relates to compositions comprising an anionic polymer, such as hyaluronate or alginate, a cation such as calcium, an anion such as phosphate, and nucleic acids such as siRNA for the SPARC gene. The compositions are used for delivery of nucleic acids to cells to thereby regulate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BUCHTA, Richard, SEET, Li Fong, ANDREWS LUKE, Michael, WONG, Tina Tzee Ling
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to compositions comprising an anionic polymer, such as hyaluronate or alginate, a cation such as calcium, an anion such as phosphate, and nucleic acids such as siRNA for the SPARC gene. The compositions are used for delivery of nucleic acids to cells to thereby regulate gene expression and treat diseases such as ocular fibrosis disorders.