AMINO ACID SEQUENCE OF RECOMBINANT TICK-BORNE ENCEPHALITIS VIRUS-LIKE PARTICLES AND THEIR USE AS A VACCINE ANTIGEN FOR PREVENTION OF TICK-BORNE ENCEPHALITIS VIRUS INFECTIONS

The first aspect of the invention relates to the amino acid sequence of the recombinant virus-like particles (VLPs) shown as the sequence number SEQ 1, based on the natural TBEV proteins: the prM and E protein. The change in the sequence of natural proteins refers, inter alia, to the introduction of additional modified sequences into the sequence of natural proteins, i.e., the signal sequence for LMSAP1 phosphatase from Leishmania mexicana, e.g., the signal sequence from the LEXSinduce3 Expression Kit expression system and P2A sequence, which result in more efficient overproduction of VLPs and increase their immunogenicity. A second aspect of the invention relates to recombinant VLPs with the amino acid sequence according to the invention (SEQ 1) for medical use in the prevention and control of tick-borne encephalitis, especially when used in a form of a vaccine component.