METAL ORGANIC FRAMEWORKS FOR REMOVAL OF ELEMENTAL IMPURITIES IN PHARMACEUTICAL PRODUCTS

METAL ORGANIC FRAMEWORKS FOR REMOVAL OF ELEMENTAL IMPURITIES IN PHARMACEUTICAL PRODUCTS

This invention relates to a method of using MOF adsorbents to remove elemental impurities from feed streams comprising active pharmaceutical ingredients (API). The process involves contacting the feed stream comprising API and elemental impurities with the MOF at purification conditions to obtain a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WESTON, Mitchell Hugh, MORRIS, William, RINAOLO, Vincent, WANG, Timothy Chiaan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
TRANSPORTING
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Beschreibung
Zusammenfassung:This invention relates to a method of using MOF adsorbents to remove elemental impurities from feed streams comprising active pharmaceutical ingredients (API). The process involves contacting the feed stream comprising API and elemental impurities with the MOF at purification conditions to obtain a purified stream with provides an API which has a concentration of the elemental impurity below its permitted daily exposure. The process can be carried in a batch mode where the MOF and feed stream are admixed in a vessel for a given amount of time or continuously by flowing the feed stream through a column or adsorbent bed containing the MOF adsorbent.