RNA MARKERS AND METHODS FOR IDENTIFYING COLON CELL PROLIFERATIVE DISORDERS

The present disclosure pertains to miRNAs that are differentially expressed in samples of an individual having colon cell proliferative disorder, or having a high risk of developing colon cell proliferative disorder, as compared to the corresponding sample of an individual not having colon cell prol...

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Bibliographische Detailangaben
Hauptverfasser:	TEWARI, Aneesha, HARVEY, Adam, ARMSTRONG, Frances, WEINBERG, David, EATON, Jesse, MAHAJAN, Shivani
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure pertains to miRNAs that are differentially expressed in samples of an individual having colon cell proliferative disorder, or having a high risk of developing colon cell proliferative disorder, as compared to the corresponding sample of an individual not having colon cell proliferative disorder, or having low risk of developing colon cell proliferative disorder, respectively. In some embodiments, the miRNAs are differentially expressed in a tissue sample or blood plasma sample of an individual having a colorectal lesion and having a high risk of developing colon cell proliferative disorder as compared to the corresponding tissue sample or blood sample of an individual having the colorectal lesion and having no risk or low risk of developing colon cell proliferative disorder. These differentially expressed miRNAs can be used as biomarkers for diagnosis, treatment, and/or prevention of a colon cell proliferative disorder, particularly, in a subject having a colorectal lesion.