IMMUNOGLOBULIN VARIANTS

IMMUNOGLOBULIN VARIANTS

The present invention provides an Fc variant of a parent IgA Fc polypeptide, wherein the Fc variant exhibits altered binding to FcαRs, wherein the Fc variant comprises at least one amino acid modification in the Fc region of the parent Fc polypeptide.

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Bibliographische Detailangaben
Hauptverfasser: GUYOT, Justine, IRIGARAY, Sebastien, BLANKENSHIP, John, SKEGRO, Darko, HOLMBERG, Brian
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides an Fc variant of a parent IgA Fc polypeptide, wherein the Fc variant exhibits altered binding to FcαRs, wherein the Fc variant comprises at least one amino acid modification in the Fc region of the parent Fc polypeptide.