ARYL OR HETEROARYL DERIVATIVE

A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic...

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Hauptverfasser: MINAMIZONO, Kunio, HOSODA, Shinnosuke, SUGIYAMA, Sakae, JOHNSON, Brett M, MARUYAMA, Akinobu, ZHAO, Wei, KAWANA, Asahi, YOKOSAKA, Takuya, KANEKO, Toshiyuki, KATO, Kenta, TAKEUCHI, Susumu, CHAKKA, Nagasree, SASAKI, Kosuke, WHITE, Ryan d, KOSHIMIZU, Masaki
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creator MINAMIZONO, Kunio
HOSODA, Shinnosuke
SUGIYAMA, Sakae
JOHNSON, Brett M
MARUYAMA, Akinobu
ZHAO, Wei
KAWANA, Asahi
YOKOSAKA, Takuya
KANEKO, Toshiyuki
KATO, Kenta
TAKEUCHI, Susumu
CHAKKA, Nagasree
SASAKI, Kosuke
WHITE, Ryan d
KOSHIMIZU, Masaki
description A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumor, and muscular dystrophy. (In the formula, Ar1, Ar2, X1-X3, R1, R3, R7, R8, L1, and L2 are as defined in the specifications.)
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ARYL OR HETEROARYL DERIVATIVE
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