NOVEL DERIVATIVE OF BETA-APOPICROPODOPHYLLIN AND PREPARATION METHOD THEREFOR

Provided are a novel derivative of β-apopicropodophyllin and a method of preparing the same, and more particularly, a compound represented by Formula 1 below, which is a novel derivative of β-apopicropodophyllin derived from podophyllotoxin, which is an anticancer agent, a method of preparing the sa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	NAM, So-Yeon, HYUN, Se-Hee, CHOI, Jong-Ryoo, CHOI, In-Young
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Provided are a novel derivative of β-apopicropodophyllin and a method of preparing the same, and more particularly, a compound represented by Formula 1 below, which is a novel derivative of β-apopicropodophyllin derived from podophyllotoxin, which is an anticancer agent, a method of preparing the same, and a composition for treating cancer, which includes the compound.In Formula 1, R is a C2 to C10 alkyl group, a Cz to C10 alkyl group containing an allyl- or alkyne, a -[CH2]n-C3 to C8 cycloalkyl group, a substituted or unsubstituted -[CH2]n-phenyl group, a substituted or unsubstituted -[CH2]n-C5 to C6 heteroaromatic group, a -C(=O)-Ci to C8 alkyl group, a substituted or unsubstituted -C(=O)-[CH2]n-phenyl group, or a substituted or unsubstituted -C(=O)-[CH2]n-C5 to C6 heteroaromatic group, wherein n is an integer of 0 to 6.