ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES ASSOCIATED WITH P13K MODULATION

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I):or a prodrug, solvate, enantiomer, stereoisomer, tautomer, or pharmaceutically acce...

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Hauptverfasser:	ANDERSON, Erin Danielle, GERASYUTO, Aleksey I, HICKEY, Eugene R, FENG, Shulu, KOLAKOWSKI, Gabrielle R, MCLEAN, Johnathan Alexander, SEVERANCE, Daniel Lee, WIDJAJA, Tien, MCELLIGOTT, David L, IRVIN, Thomas Combs, PUCA, Loredana, RAVI, Kannan Karukurichi, WELCH, Michael Brian, LONG, Katelyn Frances, ARONOW, Sean Douglas, KNIGHT, Jennifer Lynn, BOYLES, Nicholas A, KUMAR, Manoj, KLIPPEL-GIESE, Anke, MAYNE, Christopher Glenn, DAHLGREN, Markus K, KESICKI, Edward A
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I):or a prodrug, solvate, enantiomer, stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, W, X, Y, s, and Ring A are as described herein.