DRUG IN THE FORM OF A COMPLEX OF 3,3'-DIINDOLYLMETHANE WITH Beta-CYCLODEXTRIN

The invention relates to the field of medicine and the pharmaceutical industry, and can be used for production of drug forms of 3,3'-diindolylmethane and their use for treatment and prevention of diseases of a female reproductive system. A drug based on 3,3'-diindolylmethane contains β-cyclodextrin as a complexing component in the following ratio of components, wt.%: 3,3'-diindolylmethane 10-20, β-cyclodextrin 80-90. The drug may be in the form of capsules, or suppositories, or tablets, or powder for dissolution in water. A method for production of the drug based on 3,3'-diindolylmethane is that β-cyclodextrin is dissolved in water to obtain a solution concentration of 10-25% based on dry β-cyclodextrin. To the obtained solution 3,3'-diindolylmethane is added at the above mass ratio. The solution is stirred, the resulting suspension is spray dried at a gas temperature of 180 ° C, and the resulting dry product is sieved through a mesh to obtain a drug in powder form. A method of treating cervical neoplasia associated with human papillomavirus (HPV) is that the patient is administered once a vaccine against human papillomavirus, and then the patient is treated locally with a drug containing 3,3'-diindolylmethane in combination with β-cyclodextrin in the form of a vaginal tablet. The invention improves the water solubility and bioavailability of 3,3'-diindolylmethane, improves stability of the chemical composition of the drug, as well as eliminates HPV and eliminates burning sensation and discomfort during local treatment with vaginal tablets.