A CONSTRUCT FOR ARTICULAR CARTILAGE REGENERATION AND A METHOD OF PREPARATION

The base of the regeneration construct scaffold is a biodegradable polymer. The biodegradable polymer is blended with natural additives, such as cellulose and hydroxyapatite which increase tissue affinity. The regeneration construct is composed of two layers, where layer I comprises blend of biodegr...

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Bibliographische Detailangaben
Hauptverfasser:	Maciulaitis, Justinas, Krugly, Edvinas, Usas, Arvydas, Pockevicius, Alius, Martuzevicius, Dainius, Rimkunas, Augustinas, Griniute-Aukstikalne, Lauryna, Dabasinskaite, Lauryna, Malinauskas, Mantas, Ciuzas, Darius, Mickevicius, Tomas, Jankauskaite, Lina, Baniukaitiene, Odeta
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
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Beschreibung
Zusammenfassung:	The base of the regeneration construct scaffold is a biodegradable polymer. The biodegradable polymer is blended with natural additives, such as cellulose and hydroxyapatite which increase tissue affinity. The regeneration construct is composed of two layers, where layer I comprises blend of biodegradable polymer and cellulose and is prepared for cartilage tissue formation; and layer II comprises blend of biodegradable polymer, cellulose, and hydroxyapatite and is prepared for subchondral bone tissue formation. A method of preparation of construct comprises preparation of polymer solutions for layers I and II, applying of solution cryo-electrospinning, conversion of cellulose acetate to cellulose, surface modification of the regeneration construct layer I scaffold by treating with ozone, embedding of biologically active molecules in the regeneration construct scaffold layer I; sterilization of the regeneration construct layer I and II scaffold and combining of the regeneration construct layer I and II scaffolds in order to form final regeneration construct.