METHODS FOR ENGINEERING AMINO ACID AMMONIA LYASE ENZYMES AND ENZYMES THEREBY OBTAINED

Disclosed are methods, systems, components, and compositions for engineering enzymes. Particularly disclosed are methods, systems, components, and compositions for engineering phenylalanine ammonia-lyase (PAL) enzymes and isolating variant PAL enzymes with enhanced enzymatic properties. The variant...

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Hauptverfasser:	TRIVEDI, Vikas, D, NAIR, Nikhil, Unni, MOHAN, Karishma, MAYS, Zachary, CHAPPELL, Todd
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR IMPREGNATING OR COATING OF PAPER LAUNDERING LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PAPER NOT OTHERWISE PROVIDED FOR PAPER-MAKING PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D PROCESSES OF PREPARING SUCH COMPOSITIONS PRODUCTION OF CELLULOSE PULP COMPOSITIONS SPIRITS TEXTILES TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G TREATMENT OF TEXTILES OR THE LIKE TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS,FABRICS, FEATHERS, OR FIBROUS GOODS MADE FROM SUCH MATERIALS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are methods, systems, components, and compositions for engineering enzymes. Particularly disclosed are methods, systems, components, and compositions for engineering phenylalanine ammonia-lyase (PAL) enzymes and isolating variant PAL enzymes with enhanced enzymatic properties. The variant PAL enzymes disclosed herein or obtained by the methods disclosed herein may be utilized for treating diseases or disorders characterized by elevated blood levels of phenylalanine, such as phenylketonuria (PKU).