METHODS AND SYSTEMS FOR DETECTING AND QUANTIFYING A TARGET ANALYTE IN A SAMPLE BY NEGATIVE ION MODE MASS SPECTROMETRY

METHODS AND SYSTEMS FOR DETECTING AND QUANTIFYING A TARGET ANALYTE IN A SAMPLE BY NEGATIVE ION MODE MASS SPECTROMETRY

Laser diode thermal desorption coupled with tandem mass spectrometry systems and methods are described to detect at least one target analyte in a sample by negative ion mode mass spectrometry. For instance, the system and method involve desorbing a sample prepared for mass spectrometry analysis by l...

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Bibliographische Detailangaben
Hauptverfasser: AUGER, Serge, PICARD, Pierre
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
BASIC ELECTRIC ELEMENTS
ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
ELECTRICITY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Laser diode thermal desorption coupled with tandem mass spectrometry systems and methods are described to detect at least one target analyte in a sample by negative ion mode mass spectrometry. For instance, the system and method involve desorbing a sample prepared for mass spectrometry analysis by laser diode thermal desorption to obtain a desorbed sample, and then ionizing the desorbed sample under conditions to generate an ionized analyte flow comprising a superoxide radical anion (O2.−) adduct detectable by negative ion mode mass spectrometry; and then detecting the O2.− adduct by negative ion mode mass spectrometry, to thereby detect the target analyte.