PULMONARY SURFACTANT PARTICLE LOADED WITH NUCLEIC ACID OR PROTEIN FOR INHALED DELIVERY, AND METHOD FOR PRODUCING SAME

A complex in which a protein or nucleic acid is bound to a liposome prepared with a pulmonary surfactant can be selectively delivered to the lung while preserving its original form and function without damaging the structure of the protein or nucleic acid when administered in vivo. In addition, the...

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Bibliographische Detailangaben
Hauptverfasser: OH, Chan Hee, PARK, Ji Ho
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A complex in which a protein or nucleic acid is bound to a liposome prepared with a pulmonary surfactant can be selectively delivered to the lung while preserving its original form and function without damaging the structure of the protein or nucleic acid when administered in vivo. In addition, the complex is efficiently fused with the pulmonary surfactant membrane present in the alveoli to efficiently deliver the bound protein or nucleic acid (gene) to surrounding cells, and has low toxicity and excellent structural stability.