NOVEL ANUCLEATED CELLS FOR DRUG DELIVERY AND METHODS OF USE THEREOF

Methods for producing megakaryocytes and platelets derived from inducible pluripotent stem cells and comprising a therapeutic agent are provided. The present disclosure further provides methods and compositions for loading a platelet or a megakaryocyte with a therapeutic agent and for genetically mo...

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Bibliographische Detailangaben
Hauptverfasser: DYKSTRA, Brad, PETERS, Christian Gerald, SMITH, Brenden William, THON, Jonathan N, SCHULZ, Thomas Carl
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Methods for producing megakaryocytes and platelets derived from inducible pluripotent stem cells and comprising a therapeutic agent are provided. The present disclosure further provides methods and compositions for loading a platelet or a megakaryocyte with a therapeutic agent and for genetically modifying a platelet or a megakaryocyte to express an agent.