SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LI, Kangying, THURING, Johannes Wilhelmus John F, DARVILLE, Nicolas Freddy J, DAI, Xuedong, XU, Yanping, FANG, Lichao, FU, Liqiang, NG, Alicia Tee Fuay, URBANIETZ, Gregor Thomas, DENG, Xiangjun, MATON, William, Marc, ZHAO, Qiwu, LIU, Yingtao, PANDE, Vineet, CAI, Wei, QUEROLLE, Olivier Alexis Georges, CLEATOR, Edward, LIU, Lianzhu, LI, Ming
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.