HISTONE DEACETYLASE INHIBITOR HAVING NITROGEN-CONTAINING AROMATIC HETEROCYCLIC GROUP

HISTONE DEACETYLASE INHIBITOR HAVING NITROGEN-CONTAINING AROMATIC HETEROCYCLIC GROUP

A novel compound having HDAC2 inhibitory activity is provided.A compound represented by Formula (I):wherein the group represented by Formula:is a group represented by Formula:or the like, wherein R3 is each independently amino or the like, and n is an integer of 0 to 4, X1 is N or the like, X2 is N...

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Bibliographische Detailangaben
Hauptverfasser: YAMAKAWA Hidekuni, TAKAYA Kenji, YOSHIHARA Ken, ANAN Kosuke, MIZOTE Keisuke, KAI Hiroyuki, NAKAHARA Kenji
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A novel compound having HDAC2 inhibitory activity is provided.A compound represented by Formula (I):wherein the group represented by Formula:is a group represented by Formula:or the like, wherein R3 is each independently amino or the like, and n is an integer of 0 to 4, X1 is N or the like, X2 is N or the like, R4 and R5 are each independently a hydrogen atom or the like, R1 is substituted with Substituent group C or unsubstituted non-aromatic carbocyclyl or the like, Substituent group C is halogen or the like, and R2 is a hydrogen atom,or a pharmaceutically acceptable salt thereof.