MRNA CONSTRUCT FOR PROTEIN EXPRESSION, AND USE THEREOF

The present invention relates to an mRNA or mRNA construct including: (a) a region encoding a protein or peptide of interest; (b) a β-globin UTR region at the 5'end; and (c) a region at the 3'end in which BGH, BGH-IRES, or IRES-BGH is inserted. An mRNA or mRNA construct according to the pr...

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Bibliographische Detailangaben
Hauptverfasser:	CHOI, In Pyo, KIM, Tae Don, KANG, Hee Young
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to an mRNA or mRNA construct including: (a) a region encoding a protein or peptide of interest; (b) a β-globin UTR region at the 5'end; and (c) a region at the 3'end in which BGH, BGH-IRES, or IRES-BGH is inserted. An mRNA or mRNA construct according to the present invention improves intracellular expression or expression stability, and intracellular persistence of a chimeric antigen receptor or chimeric antigen receptor protein (CAR protein). In addition, the mRNA or mRNA construct increases the in vivo safety of the chimeric antigen receptor, and increases the ability thereof to kill cancer cells, and thus can be effectively used in anticancer pharmaceutical compositions and anticancer immunotherapy targeting solid tumors.