PROCESSES FOR THE PREPARATION OF ALPHA-HYDROXY ESTERS VIA GRIGNARD COUPLING AND THIOLATION REACTIONS

PROCESSES FOR THE PREPARATION OF ALPHA-HYDROXY ESTERS VIA GRIGNARD COUPLING AND THIOLATION REACTIONS

The present disclosure provides processes for preparing an alpha-hydroxy ester by addition of a vinyl Grignard reagent to an oxalate ester and thiolation of the resulting double bond. Also provided are alpha-hydroxy esters and synthetic intermediates prepared according to processes disclosed herein...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SALAKLANG, Jatuporn, NUYENS, Filip, XU, Li, HUANG, Shengshu, LAO, Ye, LI, Fangyi
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure provides processes for preparing an alpha-hydroxy ester by addition of a vinyl Grignard reagent to an oxalate ester and thiolation of the resulting double bond. Also provided are alpha-hydroxy esters and synthetic intermediates prepared according to processes disclosed herein and compositions comprising the alpha-hydroxy esters.