GLP-1 RECEPTOR AGONIST AND USE THEREOF

The present invention provides novel compounds of chemical formula 1, optical isomers of the compounds, or a pharmaceutically acceptable salts of the compounds, or the optical isomers. The compounds, isomers, and salts exhibits excellent activity as GLP-1 receptor agonists. Particularly, they, as GL...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, Jung Ho, JE, In-gyu, JEON, Woo Jin, IM, A-rang, SHIN, Jae Eui, CHANG, Min Whan, KIM, Kyeojin, KIM, Jeong-geun, JEONG, Jin Ah, KWON, Sung Wook, LEE, Jin Hee, JANG, Eun Hye, LEE, Myong Jae, SOHN, Te-ik, OH, Changmok, HONG, Changhee, HONG, Da Hae, KIM, Gunhee, PARK, Jung-eun, CHOI, Ji Hye, HEO, Jaeho, YOO, Yeongran, AN, Kyung Mi, JUN, Yearin, YOON, Hong Chul
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides novel compounds of chemical formula 1, optical isomers of the compounds, or a pharmaceutically acceptable salts of the compounds, or the optical isomers. The compounds, isomers, and salts exhibits excellent activity as GLP-1 receptor agonists. Particularly, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used therapeutic agents for metabolic diseases. In addition, they exhibits excellent pharmacological safety for cardiovascular systems.