PREPARATION METHOD FOR TRANS-CYCLOBUTANE PHTHALATE AND DERIVATIVE THEREOF

Provided are a preparation method for a trans-cyclobutane-o-dicarboxylic acid ester and a derivative thereof. The preparation method includes the following steps: in an organic solvent, catalyzing a substrate with a structure as shown in a structural formula I by using organic alkali at 50~90 DEG C so as to generate isomerization, acquiring the trans-cyclobutane-o-dicarboxylic acid ester or the derivative thereof, herein the structural formula I is as follows:each of R1, R2, R3 and R4 is independently arbitrary one of hydrogen or an alkyl of C1∼C5, and each of R5 and R6 is independently arbitrary one of alkyl of C1~C10 and benzyl. The organic alkali is used as a catalyst to catalyze the trans-cyclobutane-o-dicarboxylic acid ester with the structural formula I or the derivative thereof at 50~90 DEG C so as to generate an isomerization reaction, the process steps are shortened by one-step isomerization and efficient and simple. Reaction conditions are mild, and a special device is not required. Therefore, it is beneficial to scale-up production. In the scale-up production, a substrate conversion rate and a product yield of more than 70%, or even more than 80%, may be achieved.