MODULATION OF CELLULAR VIABILITY

Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardl...

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Bibliographische Detailangaben
Hauptverfasser:	DAVIDSON, Jennilee, CHUNG, Roger, LEE, Albert, RAYNER, Stephanie
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardless of the neuron's level or activity of endogenous cyclin F. Optionally the neuron is in a subject with a neurodegenerative condition or at risk of developing a neurodegenerative condition, typically a neurodegenerative condition associated with a neuronal TDP-43 proteinopathy.