PROCESS FOR THE PREPARATION OF 2-CYANOETHYL (4S)-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXYLATE BY RESOLUTION OF RACEMATES BY MEANS OF DIASTEREOMERIC TARTARIC ACID ESTERS

PROCESS FOR THE PREPARATION OF 2-CYANOETHYL (4S)-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXYLATE BY RESOLUTION OF RACEMATES BY MEANS OF DIASTEREOMERIC TARTARIC ACID ESTERS

The present invention relates to the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd), to a process for preparing the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd) using a chiral substituted tartaric ester of the formula (IIIa) or (IIIb), to a process for preparing the compound of formula (IVa)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PLATZEK, Johannes, LOVIS, Kai
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd), to a process for preparing the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd) using a chiral substituted tartaric ester of the formula (IIIa) or (IIIb), to a process for preparing the compound of formula (IVa) using the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd), to a process for preparing the compound of the formula (VIIa) using the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd), to a process for preparing the compound of the formula (Ia) using the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd), to the use of the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd) for preparation of one of the compounds of formula (IVa), (VIIa) and/or (Ia), to the use of a chiral substituted tartaric esters of the formula (IIIa) or (IIIb) for preparation of the diastereomeric salts (Va), (Vb), (Vc) and/or (Vd), and to the use of a chiral substituted tartaric ester of the formula (IIIa) or (IIIb) for preparation of one of the compounds of formula (IVa), (VIIa) and/or (Ia).