COMPOSITION, COMPRISING TMEM176B OR AN EXPRESSION OR ACTIVITY REGULATOR THEREOF AS AN ACTIVE INGREDIENT, FOR PREVENTION OR TREATMENT OF DEGENERATIVE BRAIN DISEASE

COMPOSITION, COMPRISING TMEM176B OR AN EXPRESSION OR ACTIVITY REGULATOR THEREOF AS AN ACTIVE INGREDIENT, FOR PREVENTION OR TREATMENT OF DEGENERATIVE BRAIN DISEASE

Provided is a composition for prophylaxis or treatment of neurodegenerative brain disease, the composition including TMEM176B as an active ingredient. The composition according to an aspect not only promotes phagocytosis of amyloid-beta in astrocytes and reduces amyloid plaques, but also exhibits an...

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Bibliographische Detailangaben
Hauptverfasser: PARK, Sanghoon, PARK, Seongjeong, KIM, Hye-Ju, KIM, Junghwan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided is a composition for prophylaxis or treatment of neurodegenerative brain disease, the composition including TMEM176B as an active ingredient. The composition according to an aspect not only promotes phagocytosis of amyloid-beta in astrocytes and reduces amyloid plaques, but also exhibits an effect of ameliorating behavior and cognitive functions in an animal model having Alzheimer's disease. Therefore, the composition can be usefully utilized for the prophylaxis and/or treatment of various neurodegenerative brain diseases.