HINGE MODIFIED ANTIBODY FRAGMENTS AND METHODS OF MAKING

HINGE MODIFIED ANTIBODY FRAGMENTS AND METHODS OF MAKING

The instant disclosure provides antibody fragments (e.g., Fab and F(ab')2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.

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Bibliographische Detailangaben
Hauptverfasser: KIM, Ingrid, MENG, Yu-Ju, G, SPIESS, Christoph, KIM, Hok, Seon
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The instant disclosure provides antibody fragments (e.g., Fab and F(ab')2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.